The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

Bone marrow-derived B cells make an important cell fate choice to develop into either
follicular B cells or marginal zone B cells in the spleen, which depends on signalling through …

The genomic region encoding the miR-17-92 microRNA (miRNA) cluster is often amplified in
lymphoma and other cancers, and cancer cells carrying this amplification have higher …

Our understanding of the origins and the biological functions of different peripheral B cell
subsets continues to evolve. Some understanding has been obtained regarding the synergy …

This article focuses on the functions of NF-κB that vitally impact lymphocytes and thus
adaptive immunity. NF-κB has long been known to be essential for many of the responses of …

Memory B cells are more heterogeneous than previously thought. Given that B cells play
powerful antibody-independent effector functions, it seems reasonable to assume division of …

Transitional cells represent a crucial step in the differentiation and selection of the mature B
cell compartment. Human transitional B cells have previously been variably identified based …

The role of adaptive immunity in myocardial recovery post myocardial infarction (MI),
particularly the immune response by B lymphocytes, remains elusive. Bone marrow immune …

S1P1 receptor expression is required for the egress of newly formed T cells from the thymus
and exit of mature T and B cells from secondary lymphoid organs. In this study, we deleted …