Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging
regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in …

Aims Microglia and infiltrated macrophages play important roles in inflammatory processes
after ischemic stroke. Modulating microglia/macrophage polarization from pro‐inflammatory …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

Stroke occurs when a cerebral blood vessel is blocked or ruptured, and it is the major cause
of death and adult disability worldwide. Various pharmacological agents have been …

Biological ageing is generally accompanied by a gradual loss of cellular functions and
physiological integrity of organ systems, the consequential enhancement of vulnerability …

Ischemic stroke is a leading cause of mortality and morbidity worldwide, with
neuroinflammation playing a key role in its pathophysiology. Microglia, the primary immune …

Background: Spinal cord injury (SCI) is a central nervous system (CNS) trauma involving
inflammation and oxidative stress, which play important roles in this trauma's pathogenesis …

Melatonin is a well-known, nighttime-produced indole found in bacteria, eukaryotic
unicellulars, animals or vascular plants. In vertebrates, melatonin is the major product of the …

To investigate the efficacy of exogenous administration of melatonin and melatonin receptor
agonists for the improvement of delirium, sleep, and other clinical outcomes of subjects in …