Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …

Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …

From genetic and etiological studies, autoimmune mechanisms underlying schizophrenia
are suspected; however, the details remain unclear. In this study, we describe …

Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is
important for the clearance of cytosolic contents to maintain cellular homeostasis and …

Summary The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing
nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 …

Schizophrenia is regarded as a neurodevelopmental disorder with its course progressing
throughout life. However, the aetiology and development of schizophrenia are still under …

Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of
histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase …

Transcription must be tightly controlled to regulate gene expression and development.
However, our understanding of the molecular mechanisms that influence transcription and …