Vitamin B 12 is an essential vitamin that is widely used in medical and food industries.
Vitamin B 12 biosynthesis is confined to few bacteria and archaea, and as such its …

Covers the period up to 2016 Bacterial-based natural products have long represented a
promising resource for the development of commercially relevant therapeutics, and more …

Optogenetic tools use colored light to rapidly control gene expression in space and time. We
designed a genetically encoded system that gives Escherichia coli the ability to distinguish …

A longstanding goal of synthetic biology has been the programmable control of cellular
functions. Central to this is the creation of versatile regulatory toolsets that allow for …

Gene expression models greatly accelerate the engineering of synthetic metabolic pathways
and genetic circuits by predicting sequence-function relationships and reducing trial-and …

A mRNA's translation rate is controlled by several sequence determinants, including the
presence of RNA structures within the N-terminal regions of its coding sequences. However …

Riboswitches are shape-changing regulatory RNAs that bind chemicals and regulate gene
expression, directly coupling sensing to cellular actuation. However, it remains unclear how …

RNA folding plays an important role in controlling protein synthesis as well as other cellular
processes. Existing models have focused on how RNA folding energetics control translation …

Low-molecular-weight hyaluronan (LMW-HA) has attracted much attention because of its
many potential applications. Here, we efficiently produced specific LMW-HAs from sucrose …

To perform their computational function, genetic circuits change states through a symphony
of genetic parts that turn regulator expression on and off. Debugging is frustrated by an …