Schizophrenia (SZ) is a neurodevelopmental disorder with a broad symptomatology,
including cognitive symptoms that are thought to arise from the prefrontal cortex (PFC). The …

Sex is often overlooked in animal and human research. Cognitive impairment associated
with schizophrenia (CIAS) remains an unmet clinical need, as current antipsychotic …

Importance Efforts to remediate the multiple cognitive function impairments in schizophrenia
should consider white matter as one of the underlying neural mechanisms. Objective To …

Background Schizophrenia (SZ) and major depressive disorders (MDD) have been
frequently linked to anatomical brain alterations. However, the relationship between brain …

Gamma-butyric acid (GABA) dysfunction has been implicated in the pathophysiology of
schizophrenia and its cognitive deficits. Proton magnetic resonance spectroscopy (MRS) …

Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for
developing Alzheimer's disease (AD). Both SZ and AD have white matter abnormalities and …

Cognitive deficits contribute to functional disability in patients with schizophrenia and may
be related to altered functional networks that serve cognition. We evaluated the integrity of …

The neurodevelopmental model of schizophrenia is supported by multi-level impairments
shared among schizophrenia and neurodevelopmental disorders. Despite schizophrenia …

The brain underpinnings of schizophrenia and bipolar disorders are multidimensional,
reflecting complex pathological processes and causal pathways, requiring multivariate …

Cognitive deficits are among the best predictors of real-world functioning in schizophrenia.
However, our understanding of how cognitive deficits relate to neuropathology and clinical …