Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

Sickle cell pain includes 3 types: acute recurrent painful crises, chronic pain syndromes, and
neuropathic pain. The acute painful crisis is the hallmark of the disease and the most …

Sickle cell disease (SCD) is a single gene disorder causing a debilitating systemic
syndrome characterised by chronic anaemia, acute painful episodes, organ infarction and …

Sickle cell anemia (SCA) is an inherited disorder associated with severe lifelong pain and
significant morbidity. The mechanisms of pain in SCA remain poorly understood. We show …

Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-
gated ion channels constitute the critical detectors and transducers of pain-causing stimuli …

Inflammation is a part of the body's natural response to tissue injury which initiates the
healing process. Unfortunately, inflammation is frequently painful and leads to …

Patients with sickle cell disease (SCD) suffer from intense pain that can start during infancy
and increase in severity throughout life, leading to hospitalization and poor quality of life. A …

Sickle cell disease (SCD) pain is associated with colder temperatures and touch and
described as “cold,”“hot,” and “shooting” suggesting hypersensitivity to tactile stimuli. Sickle …

To address the global burden of sickle cell disease (SCD) and the need for novel therapies,
the American Society of Hematology partnered with the US Food and Drug Administration to …

Subpopulations of somatosensory neurons are characterized by functional properties and
expression of receptor proteins and surface markers. CGRP expression and IB4-binding are …