Abstract The Solute Carrier 1A (SLC1A) family includes two major mammalian transport
systems—the alanine serine cysteine transporters (ASCT1-2) and the human glutamate …

Excitatory amino acid transporters (EAATs) optimize the temporal resolution and energy
demand of mammalian excitatory synapses by quickly removing glutamate from the synaptic …

Excitatory amino acid transporters (EAATs) uptake glutamate into glial cells and neurons.
EAATs achieve million-fold transmitter gradients by symporting it with three sodium ions and …

Glutamate is the most abundant excitatory neurotransmitter in the central nervous system,
and its precise control is vital to maintain normal brain function and to prevent excitotoxicity …

Progressive neuronal loss is a hallmark feature distinguishing neurodegenerative diseases
from normal ageing. However, the underlying mechanisms remain unknown. Extracellular …

Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic
synaptic transmission. They are not only coupled glutamate/Na+/H+/K+ transporters but also …

Glutamate is an essential excitatory neurotransmitter and an intermediate for energy
metabolism. Depending on the tumor site, cancer cells have increased or decreased …

Maintaining the integrity of cellular membranes is critical to protecting metabolic activities
and genetic information from the environment. Regulation of transport across membranes of …

Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system.
Once released, it binds to specific membrane receptors and transporters activating a wide …

Episodic ataxias (EAs) are rare neurological conditions affecting the nervous system and
typically leading to motor impairment. EA6 is linked to the mutation of a highly conserved …