Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

Progress toward the development of efficacious therapies for Alzheimer's disease (AD) is
halted by a lack of understanding early underlying pathological mechanisms. Systems …

Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (eg,
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …

Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular
structure acts as a barrier to protect the cell against various environmental insults and more …

There are currently no disease-modifying treatments for Alzheimer's disease (AD), and an
understanding of preclinical causal biomarkers to help target disease pathogenesis in the …

Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

Alzheimer's Disease (AD) is closely connected to aberrant lipid metabolism. However, how
early AD-like pathology synchronously influences brain and plasma lipidome in AD mice …