Conspectus Metal ions have been identified as key factors modulating the aggregation of
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …

Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

Amyloid-β (Aβ) aggregation intermediates, including oligomers and protofibrils (PFs), have
attracted attention as neurotoxic aggregates in Alzheimer's disease. However, due to the …

Amyloid fibrils are insoluble, fibrous nanostructures that accumulate extracellularly in
biological tissue during the progression of several human disorders, including Alzheimer's …

The robustness of NMR coherence transfer in proximity of a paramagnetic center depends
on the relaxation properties of the nuclei involved. In the case of Iron-Sulfur Proteins …

Transition metal ions, such as copper, are indispensable components in the biological
system. Copper ions which primarily exist in two major oxidation states Cu (I) and Cu (II) play …

Enzymatic molecular in situ self-assembly (E-MISA) that enables the synthesis of high-order
nanostructures from synthetic small molecules inside a living subject has emerged as a …

Nuclear Magnetic Resonance (NMR) spectroscopy is the ideal tool to address the structure,
reactivity and dynamics of both inorganic and biological substances. The knowledge of …

The redox activity of Cu ions bound to the amyloid‐β (Aβ) peptide is implicated as a source
of oxidative stress in the context of Alzheimer's disease. In order to explain the efficient redox …

Recent therapeutic strategies suggest that small peptides can act as aggregation inhibitors
of monomeric amyloid-β (Αβ) by inducing structural rearrangements upon complexation …