Glioma targeted therapy: insight into future of molecular approaches
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …
gliomas occur among all ages, more often seen in adults, which males are more susceptible …
Immunotherapy for glioblastoma: the promise of combination strategies
M Bausart, V Préat, A Malfanti - Journal of Experimental & Clinical Cancer …, 2022 - Springer
Glioblastoma (GBM) treatment has remained almost unchanged for more than 20 years. The
current standard of care involves surgical resection (if possible) followed by concomitant …
current standard of care involves surgical resection (if possible) followed by concomitant …
STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma
As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here …
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here …
Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect
Radiation therapy is a mainstay of cancer treatment but does not always lead to complete
tumor regression. Here we combine radiotherapy with blockade of the 'don't-eat-me'cell …
tumor regression. Here we combine radiotherapy with blockade of the 'don't-eat-me'cell …
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer
Radiotherapy (RT) of colorectal cancer (CRC) can prime adaptive immunity against tumor-
associated antigen (TAA)–expressing CRC cells systemically. However, abscopal tumor …
associated antigen (TAA)–expressing CRC cells systemically. However, abscopal tumor …
Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma
S Wang, W Yan, L Kong, S Zuo, J Wu, C Zhu… - Nature …, 2023 - nature.com
The codependency of cholesterol metabolism sustains the malignant progression of
glioblastoma (GBM) and effective therapeutics remain scarce. In orthotopic GBM models in …
glioblastoma (GBM) and effective therapeutics remain scarce. In orthotopic GBM models in …
Targeting the Siglec–sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma
Glioblastoma (GBM) is the most aggressive form of primary brain tumor, for which effective
therapies are urgently needed. Cancer cells are capable of evading clearance by …
therapies are urgently needed. Cancer cells are capable of evading clearance by …
Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma
The unique cancer-associated immunosuppression in brain, combined with a paucity of
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …
Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities
G Wang, K Zhong, Z Wang, Z Zhang, X Tang… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults.
Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and …
Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and …
STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway
Q Guo, X Chen, J Chen, G Zheng, C Xie, H Wu… - Cell Death & …, 2021 - nature.com
Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA);
however, the mechanism by which DNA damage drives OA is unclear. Previous research …
however, the mechanism by which DNA damage drives OA is unclear. Previous research …