The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

The blood–brain barrier is a dynamic multicellular interface that regulates the transport of
molecules between the blood circulation and the brain parenchyma. Proteins and peptides …

Summary Caspase-11, a cytosolic endotoxin (lipopolysaccharide: LPS) receptor, mediates
pyroptosis, a lytic form of cell death. Caspase-11-dependent pyroptosis mediates lethality in …

The generation of organoids and tissues with programmable cellular complexity,
architecture and function would benefit from the simultaneous differentiation of human …

Efficient intracellular delivery of proteins is needed to fully realize the potential of protein
therapeutics. Current methods of protein delivery commonly suffer from low tolerance for …

Hydrocarbon-stapled α-helical peptides are a new class of targeting molecules capable of
penetrating cells and engaging intracellular targets formerly considered intractable. This …

Immunotherapy has recently emerged as a powerful tool for cancer treatment. Early clinical
successes from cancer immunotherapy have led to a growing list of FDA approvals, and …

Fucoidan, a sulfated marine polysaccharide, has many potential biological functions,
including anticancer activity. Recently, fucoidan has been reported to target P-selectin …

Protein-based therapeutics represent a rapidly growing segment of approved disease
treatments. Successful intracellular delivery of proteins is an important precondition for …

The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing
the therapeutic potential of many proteins. We and others have previously shown that …