Instructions for when, where and to what level each gene should be expressed are encoded
within regulatory sequences. The importance of motifs recognized by DNA-binding …

Shifting from chemical to biotechnological processes is one of the cornerstones of 21st
century industry. The production of a great range of chemicals via biotechnological means is …

Natural genetic circuits enable cells to make sophisticated digital decisions. Building equally
complex synthetic circuits in eukaryotes remains difficult, however, because commonly used …

Phosphorus (P), an essential macronutrient for all living cells, is indispensable for
agricultural production. Although Arabidopsis (Arabidopsis thaliana) PHOSPHATE …

Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control
of gene expression. Despite many advances in the characterization of sequence motifs …

Robustness, the maintenance of a character in the presence of genetic change, can help
preserve adaptive traits but also may hinder evolvability, the ability to bring forth novel …

In yeast, ribosome production is controlled transcriptionally by tight coregulation of the 138
ribosomal protein genes (RPGs). RPG promoters display limited sequence homology, and …

The core promoter is the regulatory sequence to which RNA polymerase is recruited and
where it acts to initiate transcription. Here, we present the first comprehensive study of yeast …

The last 20 years of metabolic engineering has enabled bio-based production of fuels and
chemicals from renewable carbon sources using cost-effective bioprocesses. Much of this …

Spatial and temporal expression of genes is essential for maintaining phenotype integrity.
Transcription factors (TFs) modulate expression patterns by binding to specific DNA …