The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

Antimicrobial drug resistance is a growing threat to global public health. Multidrug resistance
among the'ESKAPE'organisms—encompassing Enterococcus faecium, Staphylococcus …

Bacterial populations vary in their stress tolerance and population structure depending upon
whether growth occurs in well-mixed or structured environments. We hypothesized that …

Antimicrobial resistance poses a serious threat to control infections due to ABC. Strategies to
curtail environmental colonization with MDR-ABD will require aggressive infection control …

Acinetobacter infections have high rates of mortality due to an increasing incidence of
infections by multidrug-resistant (MDR) and extensively-drug-resistant (XDR) strains …

Bacteria within the genus Acinetobacter (principally A. baumannii-calcoaceticus complex
[ABC]) are gram-negative coccobacilli that may cause nosocomial infections in critically ill or …

The rapid spread of the bla NDM-1 gene is a major public health concern. Here, we describe
the multidrug-resistant Proteus mirabilis strain XH1653, which contains a novel SXT/R391 …

The shrinking antibiotic development pipeline together with the global increase in antibiotic
resistant infections requires that new molecules with antimicrobial activity are developed …

Polymyxins are increasingly used as the critical last-resort therapeutic options for multidrug-
resistant Gram-negative bacteria. Unfortunately, polymyxin resistance has increased …

Sulbactam, a class A β-lactamase inhibitor, added to cefoperazone either at a fixed 8 mg/L
level of sulbactam or at a level of fixed cefoperazone: sulbactam ratio (2: 1) would constitute …