A forward-looking review of seizure prediction

DR Freestone, PJ Karoly, MJ Cook - Current opinion in neurology, 2017 - journals.lww.com
We conclude the review with an exercise in wishful thinking, which asks what the ideal
seizure prediction dataset would look like and how these data should be manipulated to …

[HTML][HTML] Critical slowing down as a biomarker for seizure susceptibility

MI Maturana, C Meisel, K Dell, PJ Karoly… - Nature …, 2020 - nature.com
The human brain has the capacity to rapidly change state, and in epilepsy these state
changes can be catastrophic, resulting in loss of consciousness, injury and even death …

Seizure prediction: science fiction or soon to become reality?

DR Freestone, PJ Karoly, ADH Peterson… - Current neurology and …, 2015 - Springer
This review highlights recent developments in the field of epileptic seizure prediction. We
argue that seizure prediction is possible; however, most previous attempts have used data …

[HTML][HTML] Distance to criticality undergoes critical transition before epileptic seizure attacks

S Liu, F Li, F Wan - Brain Research Bulletin, 2023 - Elsevier
Epilepsy is a common neurological disorder characterized by recurring seizures, but its
underlying mechanisms remain poorly understood. Despite extensive research, there are …

Focus on desynchronization rather than excitability: a new strategy for intraencephalic electrical stimulation

D de Castro Medeiros, MFD Moraes - Epilepsy & Behavior, 2014 - Elsevier
Epilepsy is a severely debilitating brain disease, often associated with premature death,
which has an urgent need for alternative methods of treatment. In fact, roughly 25% of …

[HTML][HTML] On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain's functional connectogram

VR Cota, SAV Cançado, MFD Moraes - Frontiers in Neuroinformatics, 2023 - frontiersin.org
Rationalized development of electrical stimulation (ES) therapy is of paramount importance.
Not only it will foster new techniques and technologies with increased levels of safety …

[HTML][HTML] The endocannabinoid system activation as a neural network desynchronizing mediator for seizure suppression

DC Medeiros, VR Cota, ACP Oliveira… - Frontiers in Behavioral …, 2020 - frontiersin.org
The understanding that hyper-excitability and hyper-synchronism in epilepsy are
indissociably bound by a cause-consequence relation has only recently been challenged …

The epileptic amygdala: toward the development of a neural prosthesis by temporally coded electrical stimulation

VR Cota, BMB Drabowski… - Journal of …, 2016 - Wiley Online Library
Many patients with epilepsy do not obtain proper control of their seizures through
conventional treatment. We review aspects of the pathophysiology underlying epileptic …

[HTML][HTML] Epilepsy as a dynamical system, a most needed paradigm shift in epileptology

MFD Moraes, D de Castro Medeiros, FAG Mourao… - Epilepsy & Behavior, 2021 - Elsevier
The idea of the epileptic brain being highly excitable and facilitated to synchronic activity has
guided pharmacological treatment since the early twentieth century. Although tackling …

Home-cage odors spatial cues elicit theta phase/gamma amplitude coupling between olfactory bulb and dorsal hippocampus

RR Pena, D de Castro Medeiros… - Neuroscience, 2017 - Elsevier
The brain oscillations may play a critical role in synchronizing neuronal assemblies in order
to establish appropriate sensory-motor integration. In fact, studies have demonstrated phase …