Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress

A Jurcau - International journal of molecular sciences, 2021 - mdpi.com
As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

Neuroinflammation as a factor of neurodegenerative disease: thalidomide analogs as treatments

YJ Jung, D Tweedie, MT Scerba… - Frontiers in Cell and …, 2019 - frontiersin.org
Neuroinflammation is initiated when glial cells, mainly microglia, are activated by threats to
the neural environment, such as pathogen infiltration or neuronal injury. Although …

The link between oxidative stress, redox status, bioenergetics and mitochondria in the pathophysiology of ALS

E Obrador, R Salvador-Palmer… - International Journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the
motor system. It is characterized by the degeneration of both upper and lower motor …

The glymphatic system: a new perspective on brain diseases

Z Ding, X Fan, Y Zhang, M Yao, G Wang… - Frontiers in Aging …, 2023 - frontiersin.org
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …

Rising stars: astrocytes as a therapeutic target for ALS disease

M Izrael, SG Slutsky, M Revel - Frontiers in neuroscience, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a multifactorial disease, characterized by a
progressive loss of motor neurons that eventually leads to paralysis and death. The current …

Microglia and astrocytes in amyotrophic lateral sclerosis: disease-associated states, pathological roles, and therapeutic potential

J You, MMM Youssef, JR Santos, J Lee, J Park - Biology, 2023 - mdpi.com
Simple Summary Amyotrophic lateral sclerosis (ALS) is a disease characterized by the
death of motor neurons that results in progressive muscle weakness and paralysis …

Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact

F De Marchi, I Munitic, A Amedei, JD Berry… - Neuroscience & …, 2021 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative
disease. Despite decades of research and many new insights into disease biology over the …

Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity

W Ng, SY Ng - Translational neurodegeneration, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset paralytic disease characterized by
progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem …

Why should we care about astrocytes in a motor neuron disease?

K Stoklund Dittlau, L Van Den Bosch - Frontiers in Molecular …, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults,
causing progressive degeneration of motor neurons, which results in muscle atrophy …

[HTML][HTML] In vitro and in vivo models of amyotrophic lateral sclerosis: an updated overview

AM Gois, DMF Mendonça, MAM Freire… - Brain Research Bulletin, 2020 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive, neurodegenerative disease
characterized by loss of upper motor neurons (UMN) and lower motor neurons (LMN) …