G-quadruplexes (G4s) are peculiar nucleic acid secondary structures formed by DNA or
RNA and are considered as fundamental features of the genome. Many proteins can …

Guanine-rich sequences can form G-quadruplexes (G4) in living cells, making these
structures promising anti-cancer targets. Compounds able to recognize these structures …

EGFR tyrosine kinase inhibitors have made remarkable success in targeted cancer therapy.
However, therapeutic resistance inevitably occurred and EGFR-targeting therapy has been …

DNA G-quadruplexes are essential motifs in molecular biology performing a wide range of
functions enabled by their unique and diverse structures. In this study, we focus on the …

Introduction Guanine-rich DNA sequences can fold into four-stranded noncanonical
secondary structures called G-quadruplexes (G4s) which are widely distributed in functional …

Conspectus Biomimetics is defined as a “practice of making technological design that copies
natural processes”, with the idea that “nature has already solved the challenges we are …

The nitrile containing Ru (II) polypyridyl complex [Ru (phen) 2 (11, 12-dCN-dppz)] 2+(1) is
shown to act as a sensitive infrared probe of G-quadruplex (G4) structures. UV–visible …

In the last years, traditional natural products have been the center of attention for the
scientific community and exploration of their therapeutic abilities is proceeding permanently …

Mitochondria are important drug targets for anticancer and other disease therapies. Certain
human mitochondrial DNA sequences capable of forming G-quadruplex structures (G4s) are …

Developing c-MYC transcription inhibitors that target the G-quadruplex has generated
significant interest; however, few compounds have demonstrated specificity for c-MYC G …