Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …

Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century
ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen …

The existence of IgM has been known for more than a century, but its importance in immunity
and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have …

Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …

Antibodies play a critical role in linking the adaptive immune response to the innate immune
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …

Antigen binding by serum Ig-M (IgM) protects against microbial infections and helps to
prevent autoimmunity, but causes life-threatening diseases when mistargeted. How antigen …

Innate immunity is the earliest response to invading microbes and acts to contain infection in
the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal …

Mass spectrometry–based glycoproteomics has gone through some incredible
developments over the last few years. Technological advances in glycopeptide enrichment …

Objective It has been suggested that anti–citrullinated protein antibodies (ACPAs) play an
important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic …