[HTML][HTML] Human plasma protein N-glycosylation
F Clerc, KR Reiding, BC Jansen, GSM Kammeijer… - Glycoconjugate …, 2016 - Springer
Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …
[HTML][HTML] N-glycosylation and inflammation; the not-so-sweet relation
B Radovani, I Gudelj - Frontiers in immunology, 2022 - frontiersin.org
Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …
Natural antibodies bridge innate and adaptive immunity
S Panda, JL Ding - The journal of immunology, 2015 - journals.aai.org
Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century
ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen …
ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen …
The importance of natural IgM: scavenger, protector and regulator
MR Ehrenstein, CA Notley - Nature Reviews Immunology, 2010 - nature.com
The existence of IgM has been known for more than a century, but its importance in immunity
and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have …
and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have …
The impact of glycosylation on the biological function and structure of human immunoglobulins
Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …
[HTML][HTML] Sialylation as an important regulator of antibody function
Antibodies play a critical role in linking the adaptive immune response to the innate immune
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …
Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b
Antigen binding by serum Ig-M (IgM) protects against microbial infections and helps to
prevent autoimmunity, but causes life-threatening diseases when mistargeted. How antigen …
prevent autoimmunity, but causes life-threatening diseases when mistargeted. How antigen …
Mannose‐binding lectin and innate immunity
WK Eddie Ip, K Takahashi… - Immunological …, 2009 - Wiley Online Library
Innate immunity is the earliest response to invading microbes and acts to contain infection in
the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal …
the first minutes to hours of challenge. Unlike adaptive immunity that relies upon clonal …
[HTML][HTML] Meta-heterogeneity: evaluating and describing the diversity in glycosylation between sites on the same glycoprotein
Mass spectrometry–based glycoproteomics has gone through some incredible
developments over the last few years. Technological advances in glycopeptide enrichment …
developments over the last few years. Technological advances in glycopeptide enrichment …
Anti–cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways
LA Trouw, EM Haisma, EWN Levarht… - … : Official Journal of …, 2009 - Wiley Online Library
Objective It has been suggested that anti–citrullinated protein antibodies (ACPAs) play an
important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic …
important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic …