Mesenchymal stromal/stem cells and their extracellular vesicles in liver diseases: insights on their immunomodulatory roles and clinical applications
Q Huai, C Zhu, X Zhang, H Dai, X Li, H Wang - Cell & Bioscience, 2023 - Springer
Liver disease is a leading cause of mortality and morbidity that is rising globally. Liver
dysfunctions are classified into acute and chronic diseases. Various insults, including viral …
dysfunctions are classified into acute and chronic diseases. Various insults, including viral …
[HTML][HTML] Human retinal secretome: A cross-link between mesenchymal and retinal cells
L Donato, C Scimone, S Alibrandi… - World Journal of Stem …, 2023 - ncbi.nlm.nih.gov
In recent years, mesenchymal stem cells (MSC) have been considered the most effective
source for regenerative medicine, especially due to released soluble paracrine bioactive …
source for regenerative medicine, especially due to released soluble paracrine bioactive …
Species variations in muscle stem cell-mediated immunosuppression on T cells
S Liu, P Hou, W Zhang, M Zuo, Z Liu, T Wang… - Scientific Reports, 2024 - nature.com
Muscle stem cells (MuSCs) are effective in treating inflammatory diseases driven by
overactive innate immune responses, such as colitis and acute lung injury, due to their …
overactive innate immune responses, such as colitis and acute lung injury, due to their …
Mesenchymal stromal cells restrain the Th17 cell response via L-amino-acid oxidase within lymph nodes
Q Ni, L Zhen, Z Zeng, J Yang, Y Wang, H Xu… - Cell Death & …, 2024 - nature.com
Mesenchymal stromal/stem cells (MSC) have emerged as a promising therapeutic avenue
for treating autoimmune diseases, eliciting considerable interest and discussion regarding …
for treating autoimmune diseases, eliciting considerable interest and discussion regarding …
IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells
M Zuo, J Fang, P Huang, S Liu, P Hou, S Wang… - Cell Death …, 2023 - nature.com
Muscle stem cells (MuSCs) have been demonstrated to exert impressive therapeutic efficacy
in disease settings through orchestrating inflammatory microenvironments. Nevertheless …
in disease settings through orchestrating inflammatory microenvironments. Nevertheless …
Light-activated extracellular matrix microcarriers with engineered MSCs loading for autoimmune psoriasis treatment
X Lin, L Cai, M Nie, X Wu, G Liang, L Shang… - Chemical Engineering …, 2023 - Elsevier
The stem-cell-therapy supported by hydrogel microcarriers has shown potentials in the
regulation of autoimmune diseases. Trends in this field focus on enhancing the viability and …
regulation of autoimmune diseases. Trends in this field focus on enhancing the viability and …
[HTML][HTML] 3D spheroid culture synchronizes heterogeneous MSCs into an immunomodulatory phenotype with enhanced anti-inflammatory effects
R Lu, K Zheng, Y Zhou, W Wang, Y Zhang, Y Chen… - Iscience, 2024 - cell.com
Mesenchymal stem cells (MSCs) are heterogeneous in morphology and transcriptome,
resulting in varying therapeutic outcomes. In this study, we found that 3D spheroid culture of …
resulting in varying therapeutic outcomes. In this study, we found that 3D spheroid culture of …
Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis
J Liu, YY Jiang, ZY Diao, DD Chen, RY Xia, BW Wang… - eLife, 2024 - elifesciences.org
Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis
involves abnormal accumulation of neutrophils and T-cell-related abnormalities. Pyroptosis …
involves abnormal accumulation of neutrophils and T-cell-related abnormalities. Pyroptosis …
MSC therapy ameliorates experimental gouty arthritis hinting an early COX-2 induction
JP Medina, I Bermejo-Álvarez, S Pérez-Baos… - Frontiers in …, 2023 - frontiersin.org
Objective The specific effect of Adipose-Derived Mesenchymal Stem Cells (Ad-MSC) on
acute joint inflammation, where the response mostly depends on innate immunity activation …
acute joint inflammation, where the response mostly depends on innate immunity activation …
PML‐mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions
Y Chu, Z Jiang, Z Gong, X Ji, M Zhu, Q Shang… - Cell …, 2024 - Wiley Online Library
Nuclear configuration plays a critical role in the compartmentalization of euchromatin and
heterochromatin and the epigenetic regulation of gene expression. Under stimulation by …
heterochromatin and the epigenetic regulation of gene expression. Under stimulation by …