The cell cycle is the series of events that take place in a cell, which drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the …

Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by
stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to …

INTRODUCTION During mitosis, cells compact their chromosomes into dense rod-shaped
structures to ensure their reliable transmission to daughter cells. Our work explores how …

Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a
century their internal organization remains largely unsolved. We applied chromosome …

Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA
superhelicity and unlink double-stranded DNA segments during processes such as …

Higher eukaryotic chromosomes are organized into topologically constrained functional
domains; however, the molecular mechanisms required to sustain these complex interphase …

Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for
establishing mitotic chromosome condensation. The primary roles of TOP2A in mitosis have …

When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs
associate with chromosomes, establishing a perichromosomal compartment coating the …

For cell division, negatively charged chromatin, in which nucleosome fibers (10 nm fibers)
are irregularly folded [1–5], must be condensed into chromosomes and segregated. While …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …