[HTML][HTML] Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms

H Slika, H Mansour, N Wehbe, SA Nasser… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen
species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants …

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Oxidative stress-induced endothelial dysfunction in cardiovascular diseases

A Shaito, K Aramouni, R Assaf, A Parenti, A Orekhov… - 2022 - qspace.qu.edu.qa
Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better
understanding of the mechanisms underlying CVD is key for better management or …

Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases

S Piera-Velazquez, SA Jimenez - Physiological reviews, 2019 - journals.physiology.org
Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF‐β/Smad signalling in type 2 diabetic rats

J Tian, M Zhang, M Suo, D Liu, X Wang… - Journal of cellular …, 2021 - Wiley Online Library
Diabetic cardiomyopathy (DCM) is one of the leading causes of heart failure in patients with
diabetes mellitus, with limited effective treatments. The cardioprotective effects of sodium …

The epithelial-to-mesenchymal transition as a possible therapeutic target in fibrotic disorders

J Di Gregorio, I Robuffo, S Spalletta… - Frontiers in cell and …, 2020 - frontiersin.org
Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

[HTML][HTML] SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition

ZH Liu, Y Zhang, X Wang, XF Fan, Y Zhang, X Li… - Biomedicine & …, 2019 - Elsevier
Endothelial-to-mesenchymal transition (EndMT) is closely related to the pathogenesis of
various diseases, including cardiac fibrosis. Transforming growth factor (TGF)-β1 strongly …

[HTML][HTML] Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function

Y Ding, Y Zhou, P Ling, X Feng, S Luo, X Zheng… - Theranostics, 2021 - ncbi.nlm.nih.gov
As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …

Nano‐Derived Therapeutic Formulations with Curcumin in Inflammation‐Related Diseases

C Quispe, N Cruz-Martins, ML Manca… - Oxidative Medicine …, 2021 - Wiley Online Library
Due to its vast therapeutic potential, the plant‐derived polyphenol curcumin is utilized in an
ever‐growing number of health‐related applications. Here, we report the extraction …

EndMT regulation by small RNAs in diabetes-associated fibrotic conditions: potential link with oxidative stress

R Giordo, YMA Ahmed, H Allam… - Frontiers in cell and …, 2021 - frontiersin.org
Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and
atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ …