Calibration of cardiac electrophysiology models is a fundamental aspect of model
personalization for predicting the outcomes of cardiac therapies, simulation testing of device …

Electrophysiological alterations of the myocardium caused by acute ischemia constitute a
pro-arrhythmic substrate for the generation of potentially lethal arrhythmias. Experimental …

The fickle heart: uncertainty quantification in cardiac and cardiovascular modelling and
simulation | Philosophical Transactions of the Royal Society A: Mathematical, Physical and …

Introduction: Fibrotic scar in the heart is known to act as a substrate for arrhythmias. Regions
of fibrotic scar are associated with slowed or blocked conduction of the action potential, but …

Cardiac fibrosis and other scarring of the heart, arising from conditions ranging from
myocardial infarction to ageing, promotes dangerous arrhythmias by blocking the healthy …

Species-specific computer models of the heart are a novel powerful tool in studies of life-
threatening cardiac arrhythmias. Here, we develop such a model aimed at studying …

Personalized cardiac modeling is widely used for studying the mechanisms of cardiac
arrythmias. Due to the high demanding of computational resource of modeling, the …

The influence of each ischemic component (hypoxia, hyperkalemia, and acidosis) on
arrhythmogenesis is controversial and difficult to study experimentally. In the present study …

ABSTRACT A better understanding of the mechanisms underlying ventricular arrhythmias,
as well as an improvement of the associated electrical and pharmacological therapies, are a …

Electrophysiological alterations of the myocardium caused by acute ischemia constitute a
pro-arrhythmic substrate for the generation of potentially lethal arrhythmias. Experimental …