Polo-like kinase I (PLK1), a cell cycle regulating kinase, has been shown to have oncogenic
function in several cancers. Although PLK1 inhibitors, such as BI2536, BI6727 (volasertib) …

Evidence for research over the past decade shows that epigenetic regulation mechanisms
run through the development and prognosis of tumors. Therefore, small molecular …

Medulloblastoma (MB) is a major pediatric malignant brain tumor that arises in the
cerebellum. MB tumors exhibit highly heterogeneous driven by diverse genetic alterations …

Purpose Polo-like kinase 1 (PLK1) is a protein kinase that is overexpressed in breast cancer
and may represent an attractive target for breast cancer treatment. However, few studies …

Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as
critical drivers of tumorigenesis and therapeutic targets. Characterized by substantial …

Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone
posttranslational modification, chromatin composition or organization and regulatory …

Glioma is the most common primary malignant tumor in the human brain. Although there are
a variety of treatments, such as surgery, radiation and chemotherapy, glioma is still an …

Structural-based drug design and solvent-free synthesis were combined to obtain three
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …

Cerebellar neuronal progenitors undergo a series of divisions before irreversibly exiting the
cell cycle and differentiating into neurons. Dysfunction of this process underlies many …

Polo-like kinases (PLKs) play important roles in regulating multiple aspects of cell cycle and
cell proliferation. In many cancer types, PLK family members are often dysregulated, which …