Background It is unclear whether or not the current evidence base allows definite
conclusions to be made regarding the optimal maternal circulating concentration of 25 …

Non-communicable diseases (NCDs), such as cardiovascular disease and osteoporosis,
affect individuals in all countries worldwide. Given the very high worldwide prevalence of …

Background Maternal vitamin D status has been associated with bone mass of offspring in
many, but not all, observational studies. However, maternal vitamin D repletion during …

Bodies intrigue us. They promise windows into the past that other archaeological finds
cannot by bringing us literally face to face with history. Yet'the body'is also highly contested …

Background Vitamin D insufficiency is common in women of childbearing age and
increasing evidence suggests that the risk of osteoporotic fracture in adulthood could be …

Prenatal nutritional constraint induces an altered metabolic phenotype in the offspring which
in humans confers an increased risk of non-communicable disease. Feeding a protein …

Osteoporosis is a major cause of morbidity and mortality through its association with age-
related fractures. Although most effort in fracture prevention has been directed at retarding …

The fetal origins hypothesis proposes that adult cardiovascular and metabolic disease
originate through developmental plasticity and fetal adaptations arising from failure of the …

Although 80% of the variance in bone mass is determined genetically, there are many other
factors which influence the accumulation of bone in early life and affect future risks of …

Background: Maternal nutrition during pregnancy has been linked with fetal brain
development and psychopathology in the offspring. We examined for associations of …