[HTML][HTML] Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

[HTML][HTML] Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

[HTML][HTML] New insights into the mechanisms of pulmonary edema in acute lung injury

R Herrero, G Sanchez, JA Lorente - Annals of Translational …, 2018 - ncbi.nlm.nih.gov
Appearance of alveolar protein-rich edema is an early event in the development of acute
respiratory distress syndrome (ARDS). Alveolar edema in ARDS results from a significant …

The acute respiratory distress syndrome: pathogenesis and treatment

MA Matthay, RL Zemans - Annual Review of Pathology …, 2011 - annualreviews.org
The acute respiratory distress syndrome (ARDS) causes 40% mortality in approximately
200,000 critically ill patients annually in the United States. ARDS is caused by protein-rich …

[HTML][HTML] STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

AJ Paris, KE Hayer, JH Oved, DC Avgousti… - Nature Cell …, 2020 - nature.com
Alveolar epithelial regeneration is essential for recovery from devastating lung diseases.
This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and …

[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome

JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

Mechanisms of sepsis-induced organ dysfunction

E Abraham, M Singer - Critical care medicine, 2007 - journals.lww.com
Background: The past several years have seen remarkable advances in understanding the
basic cellular and physiologic mechanisms underlying organ dysfunction and recovery …

[HTML][HTML] Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal …

SX Zheng, JX Yang, X Hu, M Li, Q Wang… - Biochemical …, 2020 - Elsevier
Vitamin D regulates cell proliferation, inhibits cytokines release at sites of inflammation and
reduces inflammatory responses. In this study, the aim was to investigate whether …

Biomarkers in acute kidney injury

CL Edelstein - Biomarkers of Kidney Disease, 2017 - Elsevier
Blood urea nitrogen (BUN) and serum creatinine (SCr) are not very sensitive and specific
markers of kidney function in acute kidney injury (AKI) as they are influenced by many renal …

Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid

BJ Fisher, D Kraskauskas, EJ Martin… - … of Physiology-Lung …, 2012 - journals.physiology.org
Bacterial infections of the lungs and abdomen are among the most common causes of
sepsis. Abdominal peritonitis often results in acute lung injury (ALI). Recent reports …