AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how …

Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor
that protects neurons in many regions of the central nervous system against insults such as …

This article shows that T cell activation-induced expression of the cytokines IL-2 and-4 is
determined by an oxidative signal originating from mitochondrial respiratory complex I. We …

Many viruses have as part of their arsenal the ability to modulate the apoptotic pathways of
the host. It is counter-intuitive that such simple organisms would be efficient at regulating this …

Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy,
and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an …

Infection with the human immunodeficiency virus (HIV) is associated with a progressive
decrease in CD4 T-cell number and a consequent impairment in host immune defenses …

Apoptotic cell death mediated by the members of the tumor necrosis factor receptor family is
an essential process involved in the regulation of cellular homeostasis during development …

Impaired ability to undergo programmed cell death in response to a wide range of external
stimuli acquires melanomas a selective advantage for progression and metastasis as well …

Stroke is the third most common cause of death in the Western world. The mechanisms of
brain damage in the affected areas are largely unknown. Hence, rational treatment …

Infection with the human immunodeficiency virus type 1 (HIV-1) leads to progressive
immunodeficiency and onset of opportunistic infections and neoplasms. The loss of immune …