[HTML][HTML] Molecular Docking and Molecular Dynamics Simulations in Related to Leishmania donovani: An Update and Literature Review
MR Challapa-Mamani, E Tomás-Alvarado… - Tropical Medicine and …, 2023 - mdpi.com
Leishmaniasis, a disease caused by Leishmania parasites and transmitted via sandflies,
presents in two main forms: cutaneous and visceral, the latter being more severe. With 0.7 to …
presents in two main forms: cutaneous and visceral, the latter being more severe. With 0.7 to …
The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis
Leishmaniasis is a parasitic disease and categorised as a neglected tropical disease (NTD).
Each year, between 70, 0000 and 1 million new cases are believed to occur. There are …
Each year, between 70, 0000 and 1 million new cases are believed to occur. There are …
[HTML][HTML] New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking …
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …
Synthetic product-based approach toward potential antileishmanial drug development
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …
(NTD) with no effective vaccines available. The available chemotherapeutics against …
Coumarins from Rutaceae: Chemical diversity and biological activities
CMS Junior, SMC Silva, EM Sales, E da Silva Velozo… - Fitoterapia, 2023 - Elsevier
Rutaceae is a family expressed by approximately 2100 species distributed in 154 genera
widespread in tropical and temperate regions of Australasia, America, and South Africa …
widespread in tropical and temperate regions of Australasia, America, and South Africa …
[HTML][HTML] Antimicrobial activity and DFT studies of a novel set of spiropyrrolidines tethered with thiochroman-4-one/chroman-4-one scaffolds
N Chouchène, A Toumi, S Boudriga, H Edziri, M Sobeh… - Molecules, 2022 - mdpi.com
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and
oxindole/acenaphthylene-1, 2-dione moieties were synthesized and characterized by …
oxindole/acenaphthylene-1, 2-dione moieties were synthesized and characterized by …
[HTML][HTML] Total synthesis of the natural chalcone lophirone E, synthetic studies toward benzofuran and indole-based analogues, and investigation of anti-leishmanial …
L Pozzetti, R Ibba, S Rossi, O Taglialatela-Scafati… - Molecules, 2022 - mdpi.com
The potential of natural and synthetic chalcones as therapeutic leads against different
pathological conditions has been investigated for several years, and this class of …
pathological conditions has been investigated for several years, and this class of …
Modulating leishmanial pteridine metabolism machinery via some new coumarin-1, 2, 3-triazoles: design, synthesis and computational studies
NW Hassan, A Sabt, MAZ El-Attar, M Ora… - European Journal of …, 2023 - Elsevier
In accordance with WHO statistics, leishmaniasis is one of the top neglected tropical
diseases, affecting around 700 000 to one million people per year. To that end, a new series …
diseases, affecting around 700 000 to one million people per year. To that end, a new series …
Isatin conjugates as antibacterial agents: a brief review
Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of …
health and well-being and put a persistent strain on the health care system. Development of …
Prediction of antileishmanial compounds: general model, preparation, and evaluation of 2-acylpyrrole derivatives
C Santiago, B Ortega-Tenezaca, I Barbolla… - Journal of Chemical …, 2022 - ACS Publications
In this work, the SOFT. PTML tool has been used to pre-process a ChEMBL dataset of pre-
clinical assays of antileishmanial compound candidates. A comparative study of different ML …
clinical assays of antileishmanial compound candidates. A comparative study of different ML …