Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …

Drug resistance is a major cause for therapeutic failure in non-small cell lung cancer
(NSCLC) leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of …

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal
overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non …

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …

Sequencing efforts led to the identification of somatic mutations that could affect the self-
renewal and differentiation of cancer-initiating cells. One such recurrent mutation targets the …

Glucocorticoid resistance is a major driver of therapeutic failure in T cell acute lymphoblastic
leukemia (T-ALL). Here, we identify the AKT1 kinase as a major negative regulator of the …

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently
associated with activating mutations in NOTCH1 and dysregulation of MYC. Here, we …

NOTCH signaling is critical for specifying the intestinal epithelial cell lineage and for
initiating colorectal adenomas and colorectal cancers (CRC). Based on evidence that …

T-cell acute lymphoblastic leukemia (ALL) is a rare disease in adults with inferior survival
outcomes compared with those seen in pediatric patients. Although potentially curable …

Purpose Ultra-high-dose-rate FLASH radiation therapy has been shown to minimize side
effects of irradiation in various organs while keeping antitumor efficacy. This property, called …