Abstract Anthracyclines, eg, doxorubicin (DOX), and anthracenediones, eg, mitoxantrone
(MTX), are drugs used in the chemotherapy of several cancer types, including solid and non …

Acute myeloid leukemia (AML) is one of the most common hematological neoplasia causing
death worldwide. The long-term overall survival is unsatisfactory due to many factors …

ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast
to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is …

The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the
pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect …

Introduction To date, no chemoresistance predictors are included in acute myeloid
leukaemia (AML) prognostic scoring systems to distinguish responding and refractory AML …

P-glycoprotein (P-gp), encoded by the ABCB1 (ATP-binding cassette transporter superfamily
B member 1) gene, is a transport protein involved in the efflux and distribution of the …

The occurrence of multidrug resistance (MDR) associated with the overexpression of the
ATP-binding cassette (ABC) protein ABCB1 in cancer cells remains a significant obstacle to …

Anthracycline uptake could be affected by efflux pumps of the ABC family. The influence of 7
SNPs of ABC genes was evaluated in 225 adult de novo acute myeloid leukemia (AML) …

Background: Anthracyclines in combination with cytarabine have been the standard therapy
for acute myeloid leukemia (AML) for decades with high efficacy. However, the majority of …

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by remarkable
toxicity and great variability in response to treatment. Plenteous pharmacogenetic studies …