G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

For cancers to develop, sustain and spread, the appropriation of key homeostatic
physiological systems that influence cell growth, migration and death, as well as …

Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

Metastasis is the major factor affecting patient survival in ovarian cancer. However, its
molecular mechanisms remain unclear. Our study used isogenic pairs of low‐and high …

Although many studies have demonstrated that components of the hemostatic system may
be involved in signaling leading to cancer progression, the potential mechanisms by which …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …