The identification of gene fusions from RNA sequencing data is a routine task in cancer
research and precision oncology. However, despite the availability of many computational …

The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated
downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors …

Four Ras guanine nucleotide-releasing proteins (RasGRP1 through 4) belong to the family
of guanine nucleotide exchange factors (GEFs). RasGRPs catalyze the release of GDP from …

Ras guanyl nucleotide releasing proteins (RasGRPs) are guanyl nucleotide exchange
factors that activate Ras and related GTPases such as Rap. Like Sos proteins, RasGRPs …

RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in
lymphocyte development. RasGRP1 is important in some cancers and autoimmune …

RasGRP proteins are activators of Ras and other related small GTPases by the virtue of
functioning as guanine nucleotide exchange factors (GEFs). In vertebrates, four RasGRP …

Missense variants are a major source of human genetic variation. Here we analyze a new
mouse missense variant, Rasgrp1 Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras …

Ras guanine nucleotide-releasing protein 1 (RasGRP1), a Ras activator, is upregulated in
hepatocellular carcinoma (HCC) and other kinds of cancer and is associated with the poor …

RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are
important regulators of cellular signaling. Aberrant expression or mutation of RasGRPs …

Ras plays a pivotal role in many cellular activities, and its subcellular compartmentalization
provides spatial and temporal selectivity. Here we report a mode of spatial regulation of Ras …