Role of the complement system in the tumor microenvironment
R Zhang, Q Liu, T Li, Q Liao, Y Zhao - Cancer Cell International, 2019 - Springer
The complement system has traditionally been considered a component of innate immunity
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer
M Liu, Z Tong, C Ding, F Luo, S Wu… - The Journal of …, 2020 - Am Soc Clin Investig
Macrophages have been linked to tumor initiation, progression, metastasis, and treatment
resistance. However, the transcriptional regulation of macrophages driving the protumor …
resistance. However, the transcriptional regulation of macrophages driving the protumor …
[HTML][HTML] Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment
KL Singel, TR Emmons, ANMNH Khan, PC Mayor… - JCI insight, 2019 - ncbi.nlm.nih.gov
Epithelial ovarian cancer (EOC) often presents with metastases and ascites. Granulocytic
myeloid–derived suppressor cells are an immature population that impairs antitumor …
myeloid–derived suppressor cells are an immature population that impairs antitumor …
Upregulation of CCT3 predicts poor prognosis and promotes cell proliferation via inhibition of ferroptosis and activation of AKT signaling in lung adenocarcinoma
K Wang, J He, C Tu, H Xu, X Zhang, Y Lv… - BMC molecular and cell …, 2022 - Springer
Background Chaperonin containing TCP1 subunit 3 (CCT3) acts as an oncogene in
cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are …
cancers, whereas its role and underlying mechanisms in lung adenocarcinoma (LUAD) are …
Gene expression and immune infiltration in melanoma patients with different mutation burden
L Wang, F Chen, R Liu, L Shi, G Zhao, Z Yan - BMC cancer, 2021 - Springer
Background Immunotherapy is a vital component in cancer treatment. However, due to the
complex genetic bases of cancer, a clear prediction index for efficacy has not been …
complex genetic bases of cancer, a clear prediction index for efficacy has not been …
C5a blockade increases regulatory T cell numbers and protects against microvascular loss and epithelial damage in mouse airway allografts
MA Khan, F Alanazi, HA Ahmed, A Vater… - Frontiers in …, 2018 - frontiersin.org
Microvascular injury during acute rejection has been associated with massive infiltration of
CD4+ T effector cells, and the formation of complement products (C3a and C5a). Regulatory …
CD4+ T effector cells, and the formation of complement products (C3a and C5a). Regulatory …
Safety, tolerability, pharmacokinetics, and pharmacodynamics of anti-C5a antibody BDB-001 for severe COVID-19: a randomized, double-blind, placebo-controlled …
G Chen, N Li, X Dai, S Tu, Z Shen, K Wu, T Jin… - Infectious Diseases and …, 2023 - Springer
Abstract Introduction Severe Coronavirus Disease 2019 (COVID-19) progresses with
inflammation and coagulation, due to an overactive complement system. Complement …
inflammation and coagulation, due to an overactive complement system. Complement …
A novel immune-related gene pair prognostic signature for predicting overall survival in bladder cancer
Y Fu, S Sun, J Bi, C Kong, L Yin - BMC cancer, 2021 - Springer
Background Bladder cancer (BC) is the ninth most common malignant tumor. We
constructed a risk signature using immune-related gene pairs (IRGPs) to predict the …
constructed a risk signature using immune-related gene pairs (IRGPs) to predict the …