Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4+ T Cells

Q Huang, J Hu, J Tang, L Xu, L Ye - Frontiers in immunology, 2019 - frontiersin.org
During viral infection, virus-specific follicular helper T cells provide important help to cognate
B cells for their survival, consecutive proliferation and mutation and eventual differentiation …

Gammaherpesviruses and B cells: a relationship that lasts a lifetime

KE Johnson, VL Tarakanova - Viral Immunology, 2020 - liebertpub.com
Gammaherpesviruses are highly prevalent pathogens that establish life-long infection and
are associated with diverse malignancies, including lymphoproliferative diseases and B cell …

Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency

CM Collins, SH Speck - PLoS pathogens, 2015 - journals.plos.org
The human gammaherpesviruses take advantage of normal B cell differentiation pathways
to establish life-long infection in memory B cells. Murine gammaherpesvirus 68 (MHV68) …

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA

AC Habison, MP de Miranda, C Beauchemin… - PLoS …, 2017 - journals.plos.org
Many pathogens, including Kaposi's sarcoma herpesvirus (KSHV), lack tractable small
animal models. KSHV persists as a multi-copy, nuclear episome in latently infected cells …

KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence

F Juillard, MP de Miranda, S Li… - Proceedings of the …, 2020 - National Acad Sciences
Viruses modulate biochemical cellular pathways to permit infection. A recently described
mechanism mediates selective protein interactions between acidic domain readers and …

Role of feline immunodeficiency virus in lymphomagenesis—Going alone or colluding?

S Kaye, W Wang, C Miller, A McLuckie, JA Beatty… - Ilar …, 2016 - academic.oup.com
Feline immunodeficiency virus (FIV) is a naturally occurring lentivirus of domestic and
nondomestic feline species. Infection in domestic cats leads to immune dysfunction via …

Dangerous liaisons: gammaherpesvirus subversion of the immunoglobulin repertoire

MA Zelazowska, K McBride, LT Krug - Viruses, 2020 - mdpi.com
A common biologic property of the gammaherpesviruses Epstein–Barr Virus and Kaposi
sarcoma herpesvirus is their use of B lymphocytes as a reservoir of latency in healthy …

The antagonism between the murine gammaherpesvirus protein kinase and global interferon regulatory factor 1 expression shapes the establishment of chronic …

CN Jondle, PA Sylvester, DL Schmalzriedt… - Journal of …, 2022 - Am Soc Microbiol
Gammaherpesviruses infect most vertebrate species and are associated with B cell
lymphomas. Manipulation of B cell differentiation is critical for natural infection and …

Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire

MA Zelazowska, Q Dong, JB Plummer… - Life science …, 2020 - life-science-alliance.org
The gammaherpesviruses (γHVs), human Kaposi sarcoma-associated herpesvirus (KSHV),
EBV, and murine γHV68 are prevalent infections associated with lymphocyte pathologies …

In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4

M Pires de Miranda, AP Quendera, CE McVey… - Journal of …, 2018 - Am Soc Microbiol
The latency-associated nuclear antigen from Kaposi's sarcoma-associated herpesvirus
(KSHV), kLANA, and its homolog from the murid herpesvirus 4 (MuHV-4), mLANA, are …