The blood vessels of the brain are lined with endothelial cells and it has been long known
that these help to regulate blood flow to the brain. However, there is increasing evidence …

Two proα1 (IV) chains, encoded by COL4A1, form trimers that contain, in addition, a proα2
(IV) chain encoded by COL4A2 and are the major component of the basement membrane in …

The developmental and molecular heterogeneity of tissue macrophages is unravelling, as
are their diverse contributions to physiology and pathophysiology. Moreover, also given …

Heterotrimers composed of collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2)
constitute one of the most abundant components of nearly all basement membranes …

Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and
deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in …

Drying battery electrodes at high rates leads to binder migration and has shown to affect the
mechanical as well as the electrochemical properties of Li-ion battery electrodes. Up to now …

Periodontal ligament stem cells (PDLSCs) can repair alveolar bone defects in periodontitis
in a microenvironment context-dependent manner. This study aimed to determine whether …

Objective: To characterize the clinical and MRI features of 2 families with adult-onset
dominant leukoencephalopathy and strokes and identify the underlying genetic cause …

Abstract COL4A1 and COL4A2 are extracellular matrix proteins that form heterotrimers and
are present in nearly all basement membranes in every organ. In the past decade, COL4A1 …

Cerebral small vessel disease (SVD) is among the most frequent causes of both stroke and
dementia. There is a growing list of genes known to be implicated in Mendelian forms of …