Quantitative protein mass spectrometry for multiplex measurement of coagulation and fibrinolytic proteins towards clinical application: What, why and how?
E Camilleri, M Kruijt, PL den Exter, SC Cannegieter… - Thrombosis …, 2024 - Elsevier
Plasma proteins involved in coagulation and fibrinolysis are essential to hemostasis.
Consequently, their circulating levels and functionality are critical in bleeding and …
Consequently, their circulating levels and functionality are critical in bleeding and …
Next Generation Sequencing strategies in venous thromboembolism: in whom and for what purpose?
DA Trégouët, M Pierre-Emmanuel - Journal of Thrombosis and …, 2024 - Elsevier
This invited review follows the oral presentation" To Sequence or Not to Sequence, That Is
Not the Question; But" When, Who, Which and What For?" Is “given during the State Of the …
Not the Question; But" When, Who, Which and What For?" Is “given during the State Of the …
Clinical and functional characterization of rare compound heterozygous mutations in the SERPINC1 gene causing severe thrombophilia
K Zhang, H Zhang, D Yu, J Pan, M Wang, H Xie - Gene, 2024 - Elsevier
Introduction Hereditary antithrombin (AT) deficiency is a rare autosomal dominant disorder
with significant clinical heterogeneity. In the study, we identified a patient with AT deficiency …
with significant clinical heterogeneity. In the study, we identified a patient with AT deficiency …
Antithrombin deficiency is associated with prothrombotic plasma fibrin clot phenotype
J Natorska, J Corral… - Thrombosis and …, 2023 - thieme-connect.com
Background Deficiency of antithrombin increases risk of venous thromboembolism. We
hypothesized that antithrombin deficiency affects fibrin clot structure and function. Methods …
hypothesized that antithrombin deficiency affects fibrin clot structure and function. Methods …
[HTML][HTML] Functional, biochemical, molecular and clinical characterization of antithrombin c. 1157T> C (p. Ile386Thr), a recurrent Polish variant with a founder effect
A Weronska, B De la Morena-Barrio… - …, 2023 - ncbi.nlm.nih.gov
The prevalence of AT deficiency, which is evaluated mainly by chromogenic methods using
anti-FXa functional assays, 2 is estimated at 0.02% to 0.2% of the general population, 3 and …
anti-FXa functional assays, 2 is estimated at 0.02% to 0.2% of the general population, 3 and …
The biological function of Serpinb9 and Serpinb9-based therapy
H Huang, Y Mu, S Li - Frontiers in Immunology, 2024 - frontiersin.org
Recent breakthroughs in discovering novel immune signaling pathways have revolutionized
different disease treatments. SERPINB9 (Sb9), also known as Proteinase Inhibitor 9 (PI-9), is …
different disease treatments. SERPINB9 (Sb9), also known as Proteinase Inhibitor 9 (PI-9), is …
Proteomics analysis of plasm exosomes in early pregnancy among normal pregnant women and those with antiphospholipid syndrome
Y Sun, Z Wang, J Li, T Wang, Y Tan - Heliyon, 2024 - cell.com
Introduction Antiphospholipid syndrome (APS) is an autoimmune disorder associated with
thrombosis and adverse obstetric outcomes. Early diagnosis and intervention can improve …
thrombosis and adverse obstetric outcomes. Early diagnosis and intervention can improve …
Clinical and Molecular Characterization of Nine Novel Antithrombin Mutations
J Kállai, R Gindele, K Pénzes-Daku, G Balogh… - International Journal of …, 2024 - mdpi.com
Antithrombin (AT) is the major plasma inhibitor of thrombin (FIIa) and activated factor X
(FXa), and antithrombin deficiency (ATD) is one of the most severe thrombophilic disorders …
(FXa), and antithrombin deficiency (ATD) is one of the most severe thrombophilic disorders …
Functional analysis of two abnormal antithrombin proteins with different intracellular kinetics
Y Imai, S Nagaya, Y Araiso, M Meguro-Horike… - Thrombosis …, 2023 - Elsevier
Introduction Hereditary antithrombin (AT) deficiency type I causes venous thrombosis due to
decreased levels of AT antigen in the blood. We identified one novel and one known …
decreased levels of AT antigen in the blood. We identified one novel and one known …
Thrombophilia Screening: Not So Straightforward
GW Moore - Seminars in Thrombosis and Hemostasis, 2024 - thieme-connect.com
Although inherited thrombophilias are lifelong risk factors for a first thrombotic episode,
progression to thrombosis is multifactorial and not all individuals with inherited …
progression to thrombosis is multifactorial and not all individuals with inherited …