Plasma proteins involved in coagulation and fibrinolysis are essential to hemostasis.
Consequently, their circulating levels and functionality are critical in bleeding and …

This invited review follows the oral presentation" To Sequence or Not to Sequence, That Is
Not the Question; But" When, Who, Which and What For?" Is “given during the State Of the …

Introduction Hereditary antithrombin (AT) deficiency is a rare autosomal dominant disorder
with significant clinical heterogeneity. In the study, we identified a patient with AT deficiency …

Background Deficiency of antithrombin increases risk of venous thromboembolism. We
hypothesized that antithrombin deficiency affects fibrin clot structure and function. Methods …

The prevalence of AT deficiency, which is evaluated mainly by chromogenic methods using
anti-FXa functional assays, 2 is estimated at 0.02% to 0.2% of the general population, 3 and …

Recent breakthroughs in discovering novel immune signaling pathways have revolutionized
different disease treatments. SERPINB9 (Sb9), also known as Proteinase Inhibitor 9 (PI-9), is …

Introduction Antiphospholipid syndrome (APS) is an autoimmune disorder associated with
thrombosis and adverse obstetric outcomes. Early diagnosis and intervention can improve …

Antithrombin (AT) is the major plasma inhibitor of thrombin (FIIa) and activated factor X
(FXa), and antithrombin deficiency (ATD) is one of the most severe thrombophilic disorders …

Introduction Hereditary antithrombin (AT) deficiency type I causes venous thrombosis due to
decreased levels of AT antigen in the blood. We identified one novel and one known …

Although inherited thrombophilias are lifelong risk factors for a first thrombotic episode,
progression to thrombosis is multifactorial and not all individuals with inherited …