The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Background Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors
without approved treatments. Methods We conducted a phase 3, international, double-blind …

The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Rheumatoid arthritis (RA) is a systemic inflammatory disorder which can cause bone and
cartilage damage leading to disability, yet the treatment remains unsatisfactory nowadays …

The lung is continuously exposed to particles, toxicants, and microbial pathogens that are
cleared by a complex mechanical, innate, and acquired immune system. Mucociliary …

Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …

Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …

Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …