Insights into the secretome of mesenchymal stem cells and its potential applications

S Eleuteri, A Fierabracci - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …

Key transcription factors in the differentiation of mesenchymal stem cells

SG Almalki, DK Agrawal - Differentiation, 2016 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent cells that represent a promising source for
regenerative medicine. MSCs are capable of osteogenic, chondrogenic, adipogenic and …

Regulation and function of SOX9 during cartilage development and regeneration

H Song, KH Park - Seminars in cancer biology, 2020 - Elsevier
Chondrogenesis is a highly coordinated event in embryo development, adult homeostasis,
and repair of the vertebrate cartilage. Fate decisions and differentiation of chondrocytes …

Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease

AR Williams, JM Hare - Circulation research, 2011 - Am Heart Assoc
Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-
renewal and differentiation with a broad tissue distribution. Initially described in bone …

[HTML][HTML] Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis

WC Zhang, N Shyh-Chang, H Yang, A Rai… - Cell, 2012 - cell.com
Identification of the factors critical to the tumor-initiating cell (TIC) state may open new
avenues in cancer therapy. Here we show that the metabolic enzyme glycine decarboxylase …

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

M Dominici, K Le Blanc, I Mueller… - …, 2006 - Taylor & Francis
The considerable therapeutic potential of human multipotent mesenchymal stromal cells
(MSC) has generated markedly increasing interest in a wide variety of biomedical …

Mesenchymal stem cells reside in virtually all post-natal organs and tissues

LS Meirelles, PC Chagastelles… - Journal of cell …, 2006 - journals.biologists.com
Mesenchymal stem cells (MSCs) are multipotent cells which can give rise to mesenchymal
and non-mesenchymal tissues in vitro and in vivo. Whereas in vitro properties such as …

Fibroblasts and mesenchymal stromal/stem cells are phenotypically indistinguishable

RA Denu, S Nemcek, DD Bloom, A Goodrich, J Kim… - Acta …, 2016 - karger.com
Background/Aims: Human mesenchymal stromal/stem cells (MSCs), derived from many
different tissues, are characterized by a fibroblast-like morphology, the expression of certain …

In search of the in vivo identity of mesenchymal stem cells

L da Silva Meirelles, AI Caplan, NB Nardi - Stem cells, 2008 - academic.oup.com
In spite of the advances in the knowledge of adult stem cells (ASCs) during the past few
years, their natural activities in vivo are still poorly understood. Mesenchymal stem cells …

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart

M Mirotsou, TM Jayawardena, J Schmeckpeper… - Journal of molecular and …, 2011 - Elsevier
Stem cells play an important role in restoring cardiac function in the damaged heart. In order
to mediate repair, stem cells need to replace injured tissue by differentiating into specialized …