Chronic degeneration of the Retinal Pigment Epithelium (RPE) is a precursor to pathological
changes in the outer retina. The RPE monolayer, which lies beneath the neuroretina, daily …

Sorsby fundus dystrophy (SFD) is an autosomal dominant macular dystrophy with an
estimated prevalence of 1 in 220,000 and an onset of disease around the 4th to 6th decade …

The common retinal diseases are age-related macular degeneration (AMD) and retinitis
pigmentosa (RP). They are usually associated with the dysfunction of retinal pigment …

Retinal pigment epithelium (RPE) is a monolayer of the pigmented cells that lies on the thin
extracellular matrix called Bruch's membrane. This monolayer is the main component of the …

Inherited retinal diseases (IRDs) represent a diverse group of genetic disorders leading to
progressive degeneration of the retina due to mutations in over 280 genes. This review …

The retinal pigment epithelium (RPE) is located between the neuroretina and the choroid,
and plays a critical role in vision. RPE cells internalise outer segments (OS) from overlying …

Dysfunction of the retinal pigment epithelium (RPE) is associated with several diseases
characterized by retinal degeneration, such as diabetic retinopathy (DR). However, it has …

Sorsby fundus dystrophy (SFD) is a rare autosomal dominant disorder with complete
penetrance affecting the macula. This is caused by a mutation in the TIMP-3. This objective …

Alzheimer's disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina
with increasing age and in eyes of age-related macular degeneration (AMD) patients. To …

Pigment epithelial cells (PECs) of the retina (RPE), ciliary body, and iris (IPE) are capable of
altering their phenotype. The main pathway of phenotypic switching of eye PECs in …