It's clearly the heart! Optical transparency, cardiac tissue imaging, and computer modelling
Recent developments in clearing and microscopy enable 3D imaging with cellular resolution
up to the whole organ level. These methods have been used extensively in neurobiology …
up to the whole organ level. These methods have been used extensively in neurobiology …
Graft–host coupling changes can lead to engraftment arrhythmia: a computational study
After myocardial infarction (MI), a significant portion of heart muscle is replaced with scar
tissue, progressively leading to heart failure. Human pluripotent stem cell‐derived …
tissue, progressively leading to heart failure. Human pluripotent stem cell‐derived …
[HTML][HTML] Conductance heterogeneities induced by multistability in the dynamics of coupled cardiac gap junctions
In this paper, we study the propagation of the cardiac action potential in a one-dimensional
fiber, where cells are electrically coupled through gap junctions (GJs). We consider gap …
fiber, where cells are electrically coupled through gap junctions (GJs). We consider gap …
Non-ohmic tissue conduction in cardiac electrophysiology: Upscaling the non-linear voltage-dependent conductance of gap junctions
DE Hurtado, J Jilberto… - PLoS computational …, 2020 - journals.plos.org
Gap junctions are key mediators of intercellular communication in cardiac tissue, and their
function is vital to sustaining normal cardiac electrical activity. Conduction through gap …
function is vital to sustaining normal cardiac electrical activity. Conduction through gap …
Adaptive-step methods for Markov-based membrane models
JM Gomes, RS Oliveira, M Lobosco… - … in Nonlinear Science …, 2020 - Elsevier
This work presents new adaptive time-step schemes based on the Uniformization method for
solving stiff electrophysiology models of excitable cells. Uniformization is a numerical …
solving stiff electrophysiology models of excitable cells. Uniformization is a numerical …
Multiparameter optimization of nonuniform passive diffusion properties for creating coarse-grained equivalent models of cardiac propagation
É Irakoze, V Jacquemet - Computers in biology and medicine, 2021 - Elsevier
The arrhythmogenic role of discrete cardiac propagation may be assessed by comparing
discrete (fine-grained) and equivalent continuous (coarse-grained) models. We aim to …
discrete (fine-grained) and equivalent continuous (coarse-grained) models. We aim to …
Modelling the electrical activity of the heart
S Alonso, RW dos Santos - Cardiovascular Computing—Methodologies …, 2019 - Springer
The electrocardiogram signal is a popular measurement of the electrical activity of the whole
heart. It reflects the interaction and diversity of the electrical activity of cells from different …
heart. It reflects the interaction and diversity of the electrical activity of cells from different …
Robust graph-based upscaling of microscale fibrotic structures
ME Farquhar, K Burrage… - 2021 Computing in …, 2021 - ieeexplore.ieee.org
Electrophysiological (and electromechanical) simulations are infamous for their
computational runtimes, and this remains a significant barrier to a full understanding of the …
computational runtimes, and this remains a significant barrier to a full understanding of the …
Gap junction dynamics induces localized conductance bistability in cardiac tissue
Connexins are specialized ionic channels that control the action potential propagation
between cardiac myocytes. In this paper, we study the connexin dynamics in a one …
between cardiac myocytes. In this paper, we study the connexin dynamics in a one …
Improved accuracy of cardiac tissue-level simulations by considering membrane resistance as a cellular-level optimization objective
E Pouranbarani, LA Berg, RS Oliveira… - 2020 42nd Annual …, 2020 - ieeexplore.ieee.org
Cardiac cellular models are utilized as the building blocks for tissue simulation. One of the
imprecisions of conventional cellular modeling, especially when the models are used in …
imprecisions of conventional cellular modeling, especially when the models are used in …