Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and
memory differentiation. Here, we developed a platform to quantify cell location in three …

Leukocyte recruitment from the vasculature into tissues is a crucial component of the
immune system but is also key to inflammatory disease. Chemokines are central to this …

Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …

Severe COVID-19 causes profound immune perturbations, but pre-infection immune
signatures contributing to severe COVID-19 remain unknown. Genome-wide association …

Glioblastoma (GBM) is the most common and malignant primary brain tumor, resulting in
poor survival despite aggressive therapies. GBM is characterized in part by a highly …

Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …

Allergic conjunctivitis (AC) is a common condition resulting from exposure to allergens such
as pollen, animal dander, or mold. It is typically mediated by allergen-induced crosslinking of …

The CCL20/CCR6 axis is implicated in the migration of CCR6+ immune cells towards
CCL20, its sole ligand, whose expression is increased during inflammatory processes and is …