Electrochemical methods for the analysis of clinically relevant biomolecules

M Labib, EH Sargent, SO Kelley - Chemical reviews, 2016 - ACS Publications
Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …

Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

L Gorgannezhad, M Umer, MN Islam, NT Nguyen… - Lab on a Chip, 2018 - pubs.rsc.org
Cell-free DNA (cfDNA) refers to short fragments of acellular nucleic acids detectable in
almost all body fluids, including blood, and is involved in various physiological and …

Development of Nucleic‐Acid‐Based Electrochemical Biosensors for Clinical Applications

Z Zhang, P Sen, BR Adhikari, Y Li… - Angewandte …, 2022 - Wiley Online Library
Nucleic acids are remarkable molecules. In addition to Watson–Crick base pairing, the
different structural motifs of these molecules can bind non‐nucleic acid targets or catalyze …

Functional DNA nanostructures for theranostic applications

H Pei, X Zuo, D Zhu, Q Huang… - Accounts of chemical …, 2014 - ACS Publications
There has been tremendous interest in constructing nanostructures by exploiting the
unparalleled ability of DNA molecules in self-assembly. We have seen the appearance of …

Electrochemical sensors

BJ Privett, JH Shin, MH Schoenfisch - Analytical Chemistry, 2010 - ACS Publications
This review covers scholarly articles published in 2008 and 2009 related to the field of
electrochemical sensors. Emphasis was given to full papers reporting on fundamental …

Binary probes for nucleic acid analysis

DM Kolpashchikov - Chemical reviews, 2010 - ACS Publications
Over the last four decades nucleic acid hybridization techniques have been widely used for
the detection of specific nucleic acid sequences. In this approach a 15-nucleotide or longer …

Triple-helix molecular switch electrochemical ratiometric biosensor for ultrasensitive detection of nucleic acids

E Xiong, Z Li, X Zhang, J Zhou, X Yan, Y Liu… - Analytical …, 2017 - ACS Publications
Biomolecular receptors such as nucleic acids that switch between two or more
conformations upon binding to a specific target can be used to build specific and sensitive …

Detecting DNA and RNA and differentiating single-nucleotide variations via field-effect transistors

KM Cheung, JM Abendroth, N Nakatsuka, B Zhu… - Nano …, 2020 - ACS Publications
We detect short oligonucleotides and distinguish between sequences that differ by a single
base, using label-free, electronic field-effect transistors (FETs). Our sensing platform utilizes …

Highly specific SNP detection using 2D graphene electronics and DNA strand displacement

MT Hwang, PB Landon, J Lee, D Choi… - Proceedings of the …, 2016 - National Acad Sciences
Single-nucleotide polymorphisms (SNPs) in a gene sequence are markers for a variety of
human diseases. Detection of SNPs with high specificity and sensitivity is essential for …

Paper electrochemical device for detection of DNA and thrombin by target-induced conformational switching

JC Cunningham, NJ Brenes, RM Crooks - Analytical chemistry, 2014 - ACS Publications
Here, we report a strategy for the design of an inexpensive paper analytical device (PAD) for
quantitative detection of oligonucleotides and proteins. Detection is based on the principle of …