The axon initial segment is a highly specialized neuronal compartment, identified almost 50
years ago by the pioneers of electron microscopy. Located in the first 50 μm of the axon, it …

Since an intact membrane is required for normal cellular homeostasis, membrane repair is
essential for cell survival. Human genetic studies, combined with the development of novel …

Autosomal dominant epilepsy with auditory features results from mutations in leucine-rich
glioma-inactivated 1 (LGI1), a soluble glycoprotein secreted by neurons. Animal models of …

Brain development and interictal function are unaffected in many paroxysmal neurological
channelopathies, possibly explained by homoeostatic plasticity of synaptic transmission …

Highlights•Several mechanisms control faithful action potential propagation along the
axon.•Action potential waveform is compartmentalized in different axonal segments.•Analog …

Homeostatic plasticity of intrinsic excitability goes hand in hand with homeostatic plasticity of
synaptic transmission. However, the mechanisms linking the two forms of homeostatic …

Action potentials (APs) are generally produced in response to complex summation of
excitatory and inhibitory synaptic inputs. While it is usually considered as a digital event …

Analysis of the presynaptic action potential's (APsyn) role in synaptic facilitation in
hippocampal pyramidal neurons has been difficult due to size limitations of axons. We …

In many neurons, subthreshold depolarization in the soma can transiently increase action-
potential (AP)-evoked neurotransmission via analog-to-digital facilitation. The mechanisms …

In the mammalian brain, synaptic transmission usually depends on presynaptic action
potentials (APs) in an all-or-none (or digital) manner. Recent studies suggest, however, that …