Introduction Glaucoma, a neuropathy characterized by increased intraocular pressure (IOP),
is the major cause of blindness worldwide and its treatment aims at reducing IOP. Areas …

Agonists and antagonists of various subtypes of G protein coupled adenosine receptors
(ARs), P2Y receptors (P2YRs), and ATP-gated P2X receptor ion channels (P2XRs) are …

(N)-Methanocarba ([3.1. 0] bicyclohexyl) adenosines and corresponding ribosides were
synthesized to identify novel A1 adenosine receptor (A1AR) agonists for CNS or peripheral …

Atrial fibrillation (AF) is a progressive arrhythmia with underlying mechanisms that are not
fully elucidated, partially due to lack of reliable and affordable animal models. Here, we …

Adenosine is a ubiquitous, endogenous purine involved in a variety of physiological and
pathophysiological regulatory mechanisms. Adenosine has been proposed as an …

Introduction Trabodenoson is an adenosine mimetic acting selectively at the A1 receptor
(A1R) subtype, involved in multiple signaling pathways including matrix metalloproteinase …

A1 adenosine receptor (A1AR) agonists have cerebroprotective, cardioprotective,
antinociceptive, and other pharmaceutical applications. We explored the structure–activity …

Purpose: To determine the efficacy of trabodenoson, an adenosine mimetic with highly
selective adenosine A 1 receptor binding properties, in a preclinical mouse model for dry …

Biventricular pacing is an important modality to improve left ventricular (LV) synchronization
and long-term function. However, the biological effects of this treatment are far from being …

The complex pathophysiology of atrial fibrillation (AF) is governed by multiple risk factors in
ways that are still elusive. Basic electrophysiological properties, including atrial effective …