Ubiquitin-like protein conjugation: structures, chemistry, and mechanism
L Cappadocia, CD Lima - Chemical reviews, 2018 - ACS Publications
Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …
Protein neddylation: beyond cullin–RING ligases
RI Enchev, BA Schulman, M Peter - Nature reviews Molecular cell …, 2015 - nature.com
NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …
RCSB Protein Data Bank: Enabling biomedical research and drug discovery
DS Goodsell, C Zardecki, L Di Costanzo… - Protein …, 2020 - Wiley Online Library
Analyses of publicly available structural data reveal interesting insights into the impact of the
three‐dimensional (3D) structures of protein targets important for discovery of new drugs …
three‐dimensional (3D) structures of protein targets important for discovery of new drugs …
NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly
K Baek, DT Krist, JR Prabu, S Hill, M Klügel… - Nature, 2020 - nature.com
Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein
ubiquitylation, which is tightly controlled by the modification of cullin with the ubiquitin-like …
ubiquitylation, which is tightly controlled by the modification of cullin with the ubiquitin-like …
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
TA Soucy, PG Smith, MA Milhollen, AJ Berger… - Nature, 2009 - nature.com
The clinical development of an inhibitor of cellular proteasome function suggests that
compounds targeting other components of the ubiquitin–proteasome system might prove …
compounds targeting other components of the ubiquitin–proteasome system might prove …
Perilous journey: a tour of the ubiquitin–proteasome system
Eukaryotic cells are equipped to degrade proteins via the ubiquitin–proteasome system
(UPS). Proteins become degraded upon their conjugation to chains of ubiquitin where they …
(UPS). Proteins become degraded upon their conjugation to chains of ubiquitin where they …
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
BA Schulman, J Wade Harper - Nature reviews Molecular cell biology, 2009 - nature.com
Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through
multienzyme cascades is a central mechanism to modulate protein functions. This process is …
multienzyme cascades is a central mechanism to modulate protein functions. This process is …
[HTML][HTML] Ubiquitin: structures, functions, mechanisms
CM Pickart, MJ Eddins - Biochimica et Biophysica Acta (BBA)-Molecular …, 2004 - Elsevier
Ubiquitin is the founding member of a family of structurally conserved proteins that regulate
a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions …
a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions …
Protein neddylation and its alterations in human cancers for targeted therapy
L Zhou, W Zhang, Y Sun, L Jia - Cellular signalling, 2018 - Elsevier
Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …