[HTML][HTML] Schizophrenia: The new etiological synthesis

MJ Rantala, S Luoto, JI Borráz-León, I Krams - … & Biobehavioral Reviews, 2022 - Elsevier
Schizophrenia has been an evolutionary paradox: it has high heritability, but it is associated
with decreased reproductive success. The causal genetic variants underlying schizophrenia …

Neuroinflammation in schizophrenia: the key role of the WNT/β-catenin pathway

A Vallée - International Journal of Molecular Sciences, 2022 - mdpi.com
Schizophrenia is a very complex syndrome involving widespread brain multi-
dysconnectivity. Schizophrenia is marked by cognitive, behavioral, and emotional …

The role of inflammation in the treatment of schizophrenia

G Fond, C Lançon, T Korchia, P Auquier… - Frontiers in …, 2020 - frontiersin.org
Background: Inflammation plays a major role in the onset and maintenance of
schizophrenia. The objective of the present work was to synthetize in a narrative review the …

Altered extracellular mRNA communication in postpartum depression is associated with decreased autophagy

LM Osborne, JL Payne, ML Sherer… - Molecular psychiatry, 2022 - nature.com
We investigated whether extracellular RNA communication, which is a recently discovered
mode of intercellular communication that is involved in a variety of important biological …

Could CRP be a differential biomarker of illness stages in schizophrenia? A systematic review and meta-analysis

V Lestra, B Romeo, C Martelli, A Benyamina… - Schizophrenia …, 2022 - Elsevier
Background Patients with schizophrenia display peripheral inflammation but the impact of
illness phase is not clear. Our meta-analysis investigated the difference in CRP levels …

Targeting gut barrier dysfunction with phytotherapies: Effective strategy against chronic diseases

P Dey - Pharmacological research, 2020 - Elsevier
The intestinal epithelial layer serves as a physical and functional barrier between the
microbe-rich lumen and immunologically active submucosa; it prevents systemic …

[HTML][HTML] Novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets

M Ľupták, D Michaličková, Z Fišar… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Schizophrenia is a severe psychiatric disorder characterized by emotional, behavioral and
cognitive disturbances, and the treatment of schizophrenia is often complicated by …

A systematic review of clozapine‐associated inflammation and related monitoring

JG Leung, L Zhang, M Markota… - … : The Journal of …, 2023 - Wiley Online Library
Clozapine is an effective antipsychotic medication used for treatment‐resistant
schizophrenia. However, it is underutilized due to rigorous hematologic monitoring …

Complete blood count inflammatory markers in treatment-resistant schizophrenia: Evidence of association between treatment responsiveness and levels of …

C Labonté, N Zhand, A Park, PD Harvey - Psychiatry research, 2022 - Elsevier
Accumulating evidence suggests that the variable response to antipsychotic treatment in
schizophrenia reflects distinct biological subtypes. The pathophysiology of schizophrenia is …

Microbiota-orientated treatments for major depression and schizophrenia

GB Fond, JC Lagier, S Honore, C Lancon, T Korchia… - Nutrients, 2020 - mdpi.com
Background and significance. There is a need to develop new hypothesis-driven treatment
for both both major depression (MD) and schizophrenia in which the risk of depression is 5 …