Engineered nanomedicines with enhanced tumor penetration

J Ding, J Chen, L Gao, Z Jiang, Y Zhang, M Li, Q Xiao… - Nano Today, 2019 - Elsevier
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …

Rational design of cancer nanomedicine: nanoproperty integration and synchronization

Q Sun, Z Zhou, N Qiu, Y Shen - Advanced materials, 2017 - Wiley Online Library
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …

[HTML][HTML] Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis

X Han, N Gong, L Xue, MM Billingsley… - Nature …, 2023 - nature.com
Lipid nanoparticle-mediated RNA delivery holds great potential to treat various liver
diseases. However, targeted delivery of RNA therapeutics to activated liver-resident …

Quantifying the ligand-coated nanoparticle delivery to cancer cells in solid tumors

Q Dai, S Wilhelm, D Ding, AM Syed, S Sindhwani… - ACS …, 2018 - ACS Publications
Coating the nanoparticle surface with cancer cell recognizing ligands is expected to facilitate
specific delivery of nanoparticles to diseased cells in vivo. While this targeting strategy is …

Applications of surface modification technologies in nanomedicine for deep tumor penetration

Z Li, X Shan, Z Chen, N Gao, W Zeng… - Advanced …, 2021 - Wiley Online Library
The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …

Bridging bio–nano science and cancer nanomedicine

M Bjornmalm, KJ Thurecht, M Michael, AM Scott… - ACS …, 2017 - ACS Publications
The interface of bio–nano science and cancer medicine is an area experiencing much
progress but also beset with controversy. Core concepts of the field eg, the enhanced …

[HTML][HTML] Towards principled design of cancer nanomedicine to accelerate clinical translation

M Souri, M Soltani, FM Kashkooli, MK Shahvandi… - Materials Today Bio, 2022 - Elsevier
Nanotechnology in medical applications, especially in oncology as drug delivery systems,
has recently shown promising results. However, although these advances have been …

Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites

J Cao, D Huang, NA Peppas - Advanced drug delivery reviews, 2020 - Elsevier
The widespread development of nanocarriers to deliver chemotherapeutics to specific tumor
sites has been motivated by the lack of selective targeting during chemotherapy inducing …

Nanoengineered immune niches for reprogramming the immunosuppressive tumor microenvironment and enhancing cancer immunotherapy

H Phuengkham, L Ren, IW Shin, YT Lim - Advanced Materials, 2019 - Wiley Online Library
Cancer immunotherapies that harness the body's immune system to combat tumors have
received extensive attention and become mainstream strategies for treating cancer. Despite …

[HTML][HTML] Aptamer-functionalized nanoparticles in targeted delivery and cancer therapy

Z Fu, J Xiang - International Journal of Molecular Sciences, 2020 - mdpi.com
Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer
therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using …