Engineered nanomedicines with enhanced tumor penetration
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
Rational design of cancer nanomedicine: nanoproperty integration and synchronization
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
[HTML][HTML] Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
Lipid nanoparticle-mediated RNA delivery holds great potential to treat various liver
diseases. However, targeted delivery of RNA therapeutics to activated liver-resident …
diseases. However, targeted delivery of RNA therapeutics to activated liver-resident …
Quantifying the ligand-coated nanoparticle delivery to cancer cells in solid tumors
Coating the nanoparticle surface with cancer cell recognizing ligands is expected to facilitate
specific delivery of nanoparticles to diseased cells in vivo. While this targeting strategy is …
specific delivery of nanoparticles to diseased cells in vivo. While this targeting strategy is …
Applications of surface modification technologies in nanomedicine for deep tumor penetration
Z Li, X Shan, Z Chen, N Gao, W Zeng… - Advanced …, 2021 - Wiley Online Library
The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …
Bridging bio–nano science and cancer nanomedicine
M Bjornmalm, KJ Thurecht, M Michael, AM Scott… - ACS …, 2017 - ACS Publications
The interface of bio–nano science and cancer medicine is an area experiencing much
progress but also beset with controversy. Core concepts of the field eg, the enhanced …
progress but also beset with controversy. Core concepts of the field eg, the enhanced …
[HTML][HTML] Towards principled design of cancer nanomedicine to accelerate clinical translation
Nanotechnology in medical applications, especially in oncology as drug delivery systems,
has recently shown promising results. However, although these advances have been …
has recently shown promising results. However, although these advances have been …
Advanced engineered nanoparticulate platforms to address key biological barriers for delivering chemotherapeutic agents to target sites
The widespread development of nanocarriers to deliver chemotherapeutics to specific tumor
sites has been motivated by the lack of selective targeting during chemotherapy inducing …
sites has been motivated by the lack of selective targeting during chemotherapy inducing …
Nanoengineered immune niches for reprogramming the immunosuppressive tumor microenvironment and enhancing cancer immunotherapy
H Phuengkham, L Ren, IW Shin, YT Lim - Advanced Materials, 2019 - Wiley Online Library
Cancer immunotherapies that harness the body's immune system to combat tumors have
received extensive attention and become mainstream strategies for treating cancer. Despite …
received extensive attention and become mainstream strategies for treating cancer. Despite …
[HTML][HTML] Aptamer-functionalized nanoparticles in targeted delivery and cancer therapy
Z Fu, J Xiang - International Journal of Molecular Sciences, 2020 - mdpi.com
Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer
therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using …
therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using …