Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
Applications of multi‐omics analysis in human diseases
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
Biological age predictors
J Jylhävä, NL Pedersen, S Hägg - EBioMedicine, 2017 - thelancet.com
The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …
ongoing for over three decades, and until recently, largely without success. Advances in the …
Tryptophan metabolism in inflammaging: from biomarker to therapeutic target
FJH Sorgdrager, PJW Naudé, IP Kema… - Frontiers in …, 2019 - frontiersin.org
Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline
of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype …
of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype …
Alzheimer's pathogenic mechanisms and underlying sex difference
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and …
EA Thévenot, A Roux, Y Xu, E Ezan… - Journal of proteome …, 2015 - ACS Publications
Urine metabolomics is widely used for biomarker research in the fields of medicine and
toxicology. As a consequence, characterization of the variations of the urine metabolome …
toxicology. As a consequence, characterization of the variations of the urine metabolome …
Quality assurance procedures for mass spectrometry untargeted metabolomics. a review
Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …
capabilities for the investigation of health and disease, as well as the wide applicability for …
Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals
Experimental studies reported biochemical actions underpinning aging processes and
mortality, but the relevant metabolic alterations in humans are not well understood. Here we …
mortality, but the relevant metabolic alterations in humans are not well understood. Here we …