[HTML][HTML] The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management

K Görlinger, A Pérez-Ferrer… - Korean journal of …, 2019 - synapse.koreamed.org
Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables
to assess viscoelastic profiles of whole blood in various clinical settings. ROTEM-guided …

Association of tranexamic acid administration with mortality and thromboembolic events in patients with traumatic injury: a systematic review and meta-analysis

V Karl, S Thorn, T Mathes, S Hess… - JAMA network …, 2022 - jamanetwork.com
Importance Tranexamic acid is widely available and used off-label in patients with bleeding
traumatic injury, although the literature does not consistently agree on its efficacy and safety …

Tranexamic acid during prehospital transport in patients at risk for hemorrhage after injury: a double-blind, placebo-controlled, randomized clinical trial

FX Guyette, JB Brown, MS Zenati, BJ Early-Young… - JAMA …, 2021 - jamanetwork.com
Importance In-hospital administration of tranexamic acid after injury improves outcomes in
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international …

H Shakur, I Roberts, B Fawole, R Chaudhri… - The Lancet, 2017 - thelancet.com
Background Post-partum haemorrhage is the leading cause of maternal death worldwide.
Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients …

Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism

SP Myers, ME Kutcher, MR Rosengart… - Journal of Trauma …, 2019 - journals.lww.com
BACKGROUND Tranexamic acid (TXA) is used as a hemostatic adjunct for hemorrhage
control in the injured patient and reduces early preventable death. However, the risk of …

Risk of epidural hematoma after neuraxial techniques in thrombocytopenic parturients: a report from the multicenter perioperative outcomes group

LO Lee, BT Bateman, S Kheterpal, TT Klumpner… - …, 2017 - pubs.asahq.org
Background Thrombocytopenia has been considered a relative or even absolute
contraindication to neuraxial techniques due to the risk of epidural hematoma. There is …

Tranexamic acid for acute hemorrhage: a narrative review of landmark studies and a critical reappraisal of its use over the last decade

H Lier, M Maegele, A Shander - Anesthesia & Analgesia, 2019 - journals.lww.com
The publication of the Clinical Randomization of an Antifibrinolytic in Significant
Hemorrhage-2 (CRASH-2) study and its intense dissemination prompted a renaissance for …

Challenging traditional paradigms in posttraumatic pulmonary thromboembolism

MM Knudson, EE Moore, LZ Kornblith, AM Shui… - JAMA …, 2022 - jamanetwork.com
Importance Pulmonary clots are seen frequently on chest computed tomography performed
after trauma, but recent studies suggest that pulmonary thrombosis (PT) and pulmonary …

Clinical use of tranexamic acid: evidences and controversies

MJ Colomina, L Contreras, P Guilabert… - Brazilian journal of …, 2022 - SciELO Brasil
Tranexamic acid (TXA) significantly reduces blood loss in a wide range of surgical
procedures and improves survival rates in obstetric and trauma patients with severe …

The impact of prehospital tranexamic acid on mortality and transfusion requirements: match-pair analysis from the nationwide German TraumaRegister DGU®

S Imach, A Wafaisade, R Lefering, A Böhmer… - Critical Care, 2021 - Springer
Background Outcome data about the use of tranexamic acid (TXA) in civilian patients in
mature trauma systems are scarce. The aim of this study was to determine how severely …