It remains unclear why some patients develop heart failure without evidence of structural
damage. One theory relates to impaired myocardial energetics and ventricular-arterial …

Conventional experimental methods for studying cardiac muscle in vitro often do not expose
the tissue preparations to a mechanical impedance that resembles the in vivo hemodynamic …

To date, the mechanical loads imposed on isolated cardiac muscle tissue in vitro have been
oversimplified. Researchers typically applied loads that are time‐invariant, resulting in either …

New Findings What is the central question of this study? Intracellular energetic processes in
quiescent cardiac muscle release 'basal'heat; during contraction, a much larger amount of …

The heat production of cardiac muscle, determined by calorimetry, can be used as a
measure of cardiac metabolism. However, heat produced while a muscle is actively …

Muscle is an amazing natural thermodynamic engine that converts chemical energy into
mechanical work. Each muscle twitch issparked'by an electrically-released pulse of calcium …

Cardiac muscle contraction results in coordinated stress-length changes that correspond to
ventricular pressure-volume changes. Each contraction cycle occurs in four sequential …

Aim Cardiac hypertrophy that occurs in response to pathological stress may become lethal if
it eventually results in heart failure. In pulmonary arterial hypertension (PAH), the increased …