Common single nucleotide variants underlying drug addiction: more than a decade of research
Drug‐related phenotypes are common complex and highly heritable traits. In the last few
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …
Rat animal models for screening medications to treat alcohol use disorders
The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …
Shortened telomeres in individuals with abuse in alcohol consumption
S Pavanello, M Hoxha, L Dioni… - … journal of cancer, 2011 - Wiley Online Library
Alcohol abuse leads to earlier onset of aging‐related diseases, including cancer at multiple
sites. Shorter telomere length (TL) in peripheral blood leucocytes (PBLs), a marker of …
sites. Shorter telomere length (TL) in peripheral blood leucocytes (PBLs), a marker of …
Piecing together the puzzle of acetaldehyde as a neuroactive agent
Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied
in the 1940s, but then research interest in this compound waned. However, in the last two …
in the 1940s, but then research interest in this compound waned. However, in the last two …
Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects
E Karahanian, ME Quintanilla… - Alcoholism: Clinical …, 2011 - Wiley Online Library
Background: While the molecular entity responsible for the rewarding effects of virtually all
drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest …
drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest …
The genetics of alcohol dependence
M Rietschel, J Treutlein - Annals of the New York Academy of …, 2013 - Wiley Online Library
Alcohol consumption dates back to the Neolithic period, and alcohol dependence
contributes substantially to the current global burden of disease. Despite this, optimal …
contributes substantially to the current global burden of disease. Despite this, optimal …
Genetics of alcohol dependence
M Kimura, S Higuchi - Psychiatry and clinical neurosciences, 2011 - Wiley Online Library
Twin, family, and adoption studies have consistently shown that genetic factors play an
important role in the pathogenesis of alcohol dependence. Numerous studies have aimed to …
important role in the pathogenesis of alcohol dependence. Numerous studies have aimed to …
Factors contributing to the escalation of alcohol consumption
Understanding factors that contribute to the escalation of alcohol consumption is key to
understanding how an individual transitions from non/social drinking to AUD and to …
understanding how an individual transitions from non/social drinking to AUD and to …
De novo-synthesized retinoic acid in ovarian antral follicles enhances FSH-mediated ovarian follicular cell differentiation and female fertility
T Kawai, N Yanaka, JAS Richards, M Shimada - Endocrinology, 2016 - academic.oup.com
Retinoic acid (RA) is the active form of vitamin A and is synthesized from retinol by two key
enzymes, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). As the …
enzymes, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). As the …
ALDH2* 2 but not ADH1B* 2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: correlation of the pharmacokinetic and …
GS Peng, YC Chen, MF Wang, CL Lai… - Pharmacogenetics and …, 2014 - journals.lww.com
Objective It has been well documented that variant alleles of both ADH1B* 2 of alcohol
dehydrogenase (ADH) and ALDH2* 2 of aldehyde dehydrogenase (ALDH) protect against …
dehydrogenase (ADH) and ALDH2* 2 of aldehyde dehydrogenase (ALDH) protect against …