Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to
mediate the mechanism of immune tolerance and provide immune homeostasis …

Immune checkpoints play important roles in immune regulation, and blocking immune
checkpoints on the cell membrane is a promising strategy in the treatment of cancer. Based …

The emergence of immunotherapy in oncology requires the discovery, validation and
subsequent adoption of robust, sensitive and specific predictive and prognostic biomarkers …

Adiponectin is an adipokine associated with the healthy obese phenotype. Adiponectin
increases insulin sensitivity and has cardio and vascular protection actions. Studies related …

Programmed cell death 1 (PD-1) and its ligands PD-L1 and PD-L2 are receptors that act in
co-stimulatory and coinhibitory immune responses. Signaling the PD-1/PD-L1 or PD-L2 …

Immune checkpoints inhibition is a privileged approach to combat cancers and other human
diseases. The TIM-3 (T cell immunoglobulin and mucin-domain containing-3) inhibitory …

Background Immune-modulatory treatments have so far shown limited clinical activity in
primary brain tumours. We aimed to investigate soluble programmed death receptor ligand 1 …

The use of monoclonal antibodies targeting PD-1/PD-L1 axis completely changed
anticancer treatment strategies. However, despite the significant improvement in overall …

Abstract PD‐1/PD‐L1 pathway is crucial to immune regulation by controlling the balance
between T cell tolerance and activation. However, the association between PD‐1/PD‐L1 …

Immune checkpoint inhibitors (ICIs) have been used for various carcinomas. However,
immune‐related adverse events have been observed. There have been few reports of …